abstract：:Management of transplant patients receiving cyclosporine therapy is complicated by interpatient and intrapatient variability in pharmacokinetic parameters caused by the drug's unpredictable bioavailability. Cyclosporine, a highly lipophilic cyclic polypeptide, has recently been reformulated using a microemulsion deliv...

journal_title：Clinical transplantation

authors： Ritschel WA

更新日期：1996-08-01 00:00:00

abstract：:We report an adult liver transplant recipient with parvovirus B19 infection, presenting as chronic transfusion-dependent anemia ensuing 1 month post-transplantation. Both serum and bone marrow cells were positive for parvovirus B19 DNA detected by polymerase chain reaction. The bone marrow biopsy revealed erythroid hy...

journal_title：Clinical transplantation

authors： Chang FY,Singh N,Gayowski T,Marino IR

更新日期：1996-06-01 00:00:00

abstract：:Acute allograft rejection in patients after cardiac transplantation is associated with intense infiltration of inflammatory cells. It has been shown in animal studies that this inflammatory process is accompanied by an induction of nitric oxide syndrome (NOS) enzyme within the grafted organ. We sought to test the hypo...

journal_title：Clinical transplantation

authors： Mügge A,Kurucay S,Böger RH,Bode-Böger SM,Schäfers HJ,Wahlers T,Frölich JC,Lichtlen PR

更新日期：1996-06-01 00:00:00

abstract：:Patients with severe liver disease and accompanying malnutrition may exhibit electrolyte disturbances including the magnesium balance. In 18 patients plasma magnesium (p-Mg) was determined at the start of the liver transplantation and during the anhepatic and reperfusion phases of the operation. The blood loss was 6.9...

journal_title：Clinical transplantation

authors： Skak C,Ejlersen E,Mogensen T,Winkel P,Secher NH

更新日期：1996-04-01 00:00:00

abstract：:Although risk factors for failure of renal retransplants have been well studied, the impact of allograft nephrectomy on subsequent renal transplantation in the cyclosporin era is not well defined. The purpose of this study is to define the effect of nephrectomy of the primary allograft on subsequent allograft survival...

journal_title：Clinical transplantation

authors： Douzdjian V,Rice JC,Carson RW,Gugliuzza KK,Fish JC

更新日期：1996-04-01 00:00:00

abstract：:The effect of HLA-DR3 gene expression was studied in black cadaveric renal allograft recipients of organs from the same donor race. From January 1984 to June 1992, 70 patients received cadaveric renal allografts at the Medical University of Southern Africa (MEDUNSA). The average age and F:M ratio was 30 years and 1: 1...

journal_title：Clinical transplantation

authors： Ngcobo TK,Becker P,Modiba MC

更新日期：1996-02-01 00:00:00

abstract：:Research with human transplant recipients has shown that mycophenolate mofetil (MMF) is a powerful and selective immunosuppressant for maintenance therapy following renal transplantation. An additional body of work suggests that it might also be a valuable tool for arresting ongoing rejection episodes. One randomized,...

journal_title：Clinical transplantation

authors：

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:As the indications for liver transplantation broaden to include older and more critically ill patients, the likelihood of encountering unsuspected cardiovascular disease increases. PURPOSE:This study examined the frequency, type, and subsequent outcome of intra- and postoperative cardiovascular complication...

journal_title：Clinical transplantation

authors： Dec GW,Kondo N,Farrell ML,Dienstag J,Cosimi AB,Semigran MJ

更新日期：1995-12-01 00:00:00

abstract：:Post-transplant erythrocytosis (PTE) has been increasingly recognized as a complication of kidney transplantation, and several risk factors have been defined. Recent evidence suggests renal function may also play a role in hematological recovery after transplantation and risk of PTE. In this study of kidney transplant...

journal_title：Clinical transplantation

authors： Nankivell BJ,Allen RD,O'Connell PJ,Chapman JR

更新日期：1995-10-01 00:00:00

abstract：:Renal transplantation offers patients with end-stage renal disease the best opportunity for rehabilitation and long-term survival. However, there is a critical shortage of transplantable kidneys worldwide. This plays well into the hands of transplanters and entrepreneurs involved in commercial renal transplantation, p...

journal_title：Clinical transplantation

authors： Qunibi W,Abulrub D,Shaheen F,el-Din AB,Alfurayh O,Almeshari K

更新日期：1995-08-01 00:00:00

abstract：:Omega-3 fatty acids have been shown to play a role in preventing development of both acute and chronic rejection. New evidence also suggests that HMGCoA reductase inhibitors may have an immunomodulatory effect and may decrease the incidence of rejection in both animal and human transplant models. Omega-3 fatty acids a...

journal_title：Clinical transplantation

authors： Katznelson S,Wilkinson AH

更新日期：1995-06-01 00:00:00

abstract：:To assess the prevalence and long-term impact of HCV on kidney transplant recipients, we assayed 716 pre-transplant sera using a first-generation ELISA. The anti-HCV positive sera were confirmed by a 6-antigen radioimmunoassay (RIA). Patients were followed up for 5 years. Graft survival, function, evidence of chemical...

journal_title：Clinical transplantation

authors： Orloff SL,Stempel CA,Wright TL,Tomlanovich SJ,Amend WJ,Stock PG,Melzer JS,Vincenti F

更新日期：1995-04-01 00:00:00

abstract：:The concept of a narrow therapeutic window has guided the management of transplant recipients on cyclosporine immunosuppression since its inception more than a decade ago. The need to maintain immunosuppression and avoid toxicity imposed the requirement of monitoring cyclosporine levels within a limited range. The use...

journal_title：Clinical transplantation

authors： Takasugi M,Takasugi JK,Barba L

更新日期：1995-04-01 00:00:00

abstract：:Living-related liver transplantation (LRLT) in pediatric recipients has been successful with 90% 1-year survival (1, 2). LRLT in adults is yet to succeed. We hypothesize a management strategy based on the donor graft weight-to-recipient body weight ratio (GRBWR) and the Redox Tolerance Index (RTI) (3). Favorable recip...

journal_title：Clinical transplantation

authors： Habib N,Tanaka K

更新日期：1995-02-01 00:00:00

abstract：:Proven Pneumocystis carinii pneumonia (PCP) occurred in 8 (5.2%) of 154 adult liver transplant recipients between January 1986 and December 1992. The interval between transplantation and PCP ranged from 69 to 131 days with a mean of 95 days (SD 20 days). The PaO2 breathing room air at diagnosis ranged from 40 mmHg to ...

journal_title：Clinical transplantation

authors： Hayes MJ,Torzillo PJ,Sheil AG,McCaughan GW

更新日期：1994-12-01 00:00:00

abstract：:Cutaneous cryptococcosis is an uncommon manifestation of disseminated cryptococcal disease. We report a liver transplant recipient presenting with onset over 3 days of progressive pain and swelling of the lower extremity and foot with erythema and heat. Cryptococcal cellulitis was documented, but in retrospect the cli...

journal_title：Clinical transplantation

authors： Singh N,Rihs JD,Gayowski T,Yu VL

更新日期：1994-08-01 00:00:00

abstract：:In a retrospective analysis of stable cadaveric renal transplant patients we identified 19 patients with high (> 270 mg/dl) and 12 patients with low (< 170 mg/dl) serum cholesterol levels. We found that patients with high cholesterol level had higher serum cyclosporine levels despite similar oral dose of cyclosporine,...

journal_title：Clinical transplantation

authors： Bastani B,Rittenhouse M,Garvin P

更新日期：1994-08-01 00:00:00

abstract：:Steroid withdrawal has potential risks (rejection) and benefits (fewer complications). Most data on steroid-related complications predates cyclosporine (CsA). We tabulated the incidence of posttransplant complications considered to be steroid-related in 748 adult kidney transplant recipients (with at least 1 year of f...

journal_title：Clinical transplantation

authors： Fryer JP,Granger DK,Leventhal JR,Gillingham K,Najarian JS,Matas AJ

更新日期：1994-06-01 00:00:00

abstract：:As there are other lesions in the cardiac allografts of long-term survivors, it is best to refer to the vascular lesion as "graft vascular disease". Graft vascular disease may be evident as early as 3 months after cardiac transplantation and may cause death in the recipient as late as 22 years post-transplant. The dis...

journal_title：Clinical transplantation

authors： Billingham ME

更新日期：1994-06-01 00:00:00

abstract：:15-deoxyspergualin (DSG) is a novel immunosuppressant which has been shown to be effective in preventing and treating rejection in animal allo- and xenotransplant models. Preliminary clinical studies suggest that DSG is an effective antirejection agent. In our study, 4 patients with biopsy-proven rejection episodes th...

journal_title：Clinical transplantation

authors： Matas AJ,Gores PF,Kelley SL,Bielefield-Skrokov M,Kinaszczuk M,Gruessner RW,Najarian JS

更新日期：1994-04-01 00:00:00

abstract：:The transplantation of vascularized organs between species stimulates an intense rejection reaction by the recipient of the graft. The classification of the xenograft rejection reaction on the basis of the degree of genetic disparity between donor and recipient species and the presence or absence of preformed antibody...

journal_title：Clinical transplantation

authors： Makowka L,Cramer DV

更新日期：1994-04-01 00:00:00

abstract：:Cell-mediated responses to xenoantigens are different from those to alloantigens. CD4+ T cells are especially important in xenoresponses and depletion of CD4+ T cells can prolong survival of xenografts better than allografts in some circumstances. The difference between the two responses is due in part to the relative...

journal_title：Clinical transplantation

authors： Auchincloss H Jr

更新日期：1994-04-01 00:00:00

abstract：:The objective of this meta-analysis was to review the evidence for the use of immune globulin in the prevention of symptomatic cytomegalovirus (CMV) disease in transplant recipients. A computerized search of Medline from 1980 to October 1991 was conducted using the textword "cytomegalo:" and the subheading "prevention...

journal_title：Clinical transplantation

authors： Glowacki LS,Smaill FM

更新日期：1994-02-01 00:00:00

abstract：:Accurate prognostic indicators are lacking for livers with early marginal graft function, making the decision to re-transplant a difficult one. Therefore, we studied 99mTc-labeled DISIDA scanning as a predictor of recovery of marginal grafts. Records of 28 liver transplant recipients with prolonged periods of marginal...

journal_title：Clinical transplantation

authors： Karademir S,Csete ME,Jurim O,Finstad T,Hawkins R,Bussuttil RW,Shaked A

更新日期：1994-02-01 00:00:00

abstract：:The role of the liver biopsy for establishing a diagnosis of liver allograft rejection was investigated by examining under code 151 liver biopsies from 32 recipients and correlating the results with the clinical diagnosis determined by chart review. One-hundred-and-four biopsies were obtained to evaluate the cause of...

journal_title：Clinical transplantation

authors： Aran PP,Bissel MG,Whitington PF,Bostwick DG,Adamac T,Baker AL

更新日期：1993-10-01 00:00:00

abstract：:Of 1463 liver allograft recipients receiving the combination of FK506 and steroids as their primary immunosuppressive regimen, 2 patients developed Kaposi's sarcoma. Although previously described as a complication of organ transplantation, this is the first case report of Kaposi's sarcoma occurring in association with...

journal_title：Clinical transplantation

authors： Kadry Z,Bronsther O,Van Thiel DH,Randhawa P,Fung JJ,Starzl TE

更新日期：1993-01-01 00:00:00

abstract：:We have experienced 5 hepatic vein stenoses in 3 children (8 to 23 months old) after living-related liver transplantation (total 48 liver transplants for 48 children between June 1990 and November 1992). The initial symptoms of hepatic vein stenosis were ascites and/or edema. The blood flow of hepatic vessels was mon...

journal_title：Clinical transplantation

authors： Egawa H,Tanaka K,Uemoto S,Someda H,Moriyasu F,Sano K,Nishizawa F,Ozawa K

更新日期：1993-01-01 00:00:00

abstract：:There is currently an imbalance between the need for cadaveric kidneys for transplantation and the supply. The medical criteria for accepting cadaveric donors are changing and organs that were originally thought to be unacceptable have functioned well. Previous reports have discussed the problems with transplanting ...

journal_title：Clinical transplantation

authors： Jacoby K,Lippman HR,Hura CE,McFarlin L,Jones CF,Banowsky LH

更新日期：1992-12-01 00:00:00

abstract：:There is evidence to suggest that long-term survival of discordant xenografts may be possible if the organ is transplanted at a time when the host natural anti-species (xenoreactive) antibodies are temporarily absent or otherwise inhibited from reacting with the donor antigens. There is also evidence that the target ...

journal_title：Clinical transplantation

authors： Cooper DK

更新日期：1992-06-01 00:00:00

abstract：:The effect of storage temperature on early graft function following liver transplantation was investigated by analyzing the results following transplantation during three periods in which different techniques for graft storage were used. The techniques involved ice-packing (period 1), storage in a standard operating ...

journal_title：Clinical transplantation

authors： Morino M,Adam R,Diamond T,Castaing D,Reynes M,Bismuth H

更新日期：1992-04-01 00:00:00

abstract：:The importance of the size of the infused marrow cell dose (MCD) was investigated in 274 patients undergoing allogeneic BMT between 1975 and 1990. Among those, 65 had acute myelogenous leukemia (AML), 79 acute lymphoblastic leukemia (ALL), 58 chronic myelogenous leukemia (CML) and 25 severe aplastic anemia (SAA). MC...

journal_title：Clinical transplantation

authors： Paulin T

更新日期：1992-02-01 00:00:00

abstract：:Organ donor availability is the major limiting factor in pediatric liver transplantation, and many children succumb from their liver disease before a suitable donor can be found. In an attempt to overcome this shortage, reduced-size liver transplantation, split liver transplantation, and living-donor liver transplanta...

journal_title：Clinical transplantation

authors： Emond JC,Whitington PF,Broelsch CE

更新日期：1991-04-01 00:00:00

abstract：:Lymphocyte cultures grown from liver allograft biopsies were shown to exhibit alloreactivity towards donor cells as measured by primed lymphocyte testing (PLT). The PLT specificity was determined in assays using HLA typed panel cells and/or by inhibition testing with HLA specific monoclonal antibodies. Certain culture...

journal_title：Clinical transplantation

authors： Markus BH,Demetris AJ,Saidman S,Fung JJ,Zeevi A,Starzl TE,Duquesnoy RJ

更新日期：1988-01-01 00:00:00